Source: Bleedingcool.com
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Marvel/Timely's Miss America debuted in Marvel Mystery Comics #49, cover-dated November 1943. Created by Otto Binder and Al Gabriele, that issue told the story of Madeline Joyce, the teenage ward of radio tycoon James Bennet. Bennet was funding the experiments of scientist Professor Lawson, who developed an electrically-charged apparatus that gave him superpowers.
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Madeline quickly decided that she wanted such power herself, and used Professor Lawson's device without authorization. Although it almost killed her, the process worked, giving Madeline great strength and the ability to fly, among other powers. After several months of appearing in Marvel Mystery Comics, Miss America got her own title with Miss America Comics #1 in 1944.
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Miss America was one of the first female superheroes of the Timely/Marvel line, and this one-shot gave rise to the long-running Miss America Magazine.
Marvel Mystery Comics #49 (Timely, 1943) CGC FN+ 6.0 White Pages. Origin of Miss America. Japanese war, Rising Sun, bondage cover by Syd Shores. Art by Shores, Harry Sahle, and Al Gabriele. Overstreet 2021 FN 6.0 value = $1,182; VF 8.0 value = $2,158. CGC census 11/21: 5 in 6.0, 13 higher. Total 38 on census